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het@alligatorbioscience.se
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Scientific Advisors

 




Professor Thomas Tötterman, Clinical Immunology Division, Department of Immunology, Genetics & Pathology, Uppsala University, is an internationally recognized pioneer in the field of cancer immunotherapy. Alligator Bioscience has an extensive scientific collaboration with Professor Tötterman and his group that has led to the development of the IMCAN (IMmunotherapy of CANcer) concept for local immunotherapy of cancer. The Alligator pipeline has two projects within the IMCAN concept, ADC-1013 and ADC-1014, and Professor Tötterman is now involved in the pre-clinical development of these two projects. Thomas Tötterman received his MD from the University of Helsinki, 1975 and his PhD from the same University 1978. He was appointed Professor/Senior Consultant in Clinical Immunology 1995 and was President for the Swedish Society of Gene and Cell Therapy (SSGCT) 2006-2010. Thomas Tötterman has been Initiator/Sponsor of two academic phase I/II trials, “first-in-man”, studies with immunomodulatory drug candidates. He has published more than 170 peer-reviewed scientific papers including several reviews.





Professor and Senior Consultant Mattias Belting, Medical Faculty, Department of Oncology, and Skåne Oncology Clinic, Lund University, heads a research group focusing on the role of the tumor microenvironment in cancer development and metastasis. Belting's group has published several internationally recognized papers in top ranked journals such as Nature Medicine, Proceedings of the National Academy of Sciences, Blood, and Cancer Research, on the molecular events involved in the formation and progression of malignant tumors, and on the development of novel strategies for targeted drug delivery to tumors. Professor Belting is guiding Alligator Bioscience´s development of drug compounds optimized for efficacy in the tumor microenvironment, as well as the pre-clinical and clinical development of these compounds.


 
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